U-99194 (maleate)
Catalogue number:
CAY35854-5 mg
Supplier:
Size:
5 mg
Product is available in:
£81.00
Estimated delivery Mon 5 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
234757-41-6
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C17H27NO2 • C4H4O4
Molecular Weight:
393.5
Alternative Names:
2,3-dihydro-
Product Description:
A dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor); selective for dopamine D3 receptors over the α1-AR (Ki = 8,913 nM for the rat receptor), M1 mAChR, 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors); reverses (+)-7-OH-DPAT- or PD 128907-induced hypothermia in rats (ID50s = 19.1 and 12.9 mg/kg, respectively); increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness at 40 mg/kg