U-99194 (maleate)
Catalogue number:
CAY35854-5 mg
Supplier:
Size:
5 mg
Product is available in:
£81.00
Estimated delivery Thu 19 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
234757-41-6
Alternative Names:
2,3-dihydro-
Product Description:
A dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor); selective for dopamine D3 receptors over the α1-AR (Ki = 8,913 nM for the rat receptor), M1 mAChR, 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors); reverses (+)-7-OH-DPAT- or PD 128907-induced hypothermia in rats (ID50s = 19.1 and 12.9 mg/kg, respectively); increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness at 40 mg/kg