(R)-ErSO
Catalogue number:
CAY35684-10 mg
Supplier:
Size:
10 mg
Product is available in:
£902.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2407860-35-7
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C22H13F6NO3
Molecular Weight:
453.3
Alternative Names:
(3r)-1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-2h-indol-2-one, erso
Product Description:
An activator of the anticipatory unfolded protein response; inhibits protein synthesis and induces intracellular ATP depletion in T47D cells at 1 µM ; increases levels of phosphorylated EIF2AK3, eIF2α, and AMPK in T47D cells at 1 µM; cytotoxic to T47D, TYS, BT474, and ZR-75-1 ERα-positive breast cancer cells (IC50s = 16.4, 11.1, 26.9, and 42.8 nM, respectively); induces tumor regression in an MCF-7 mouse xenograft model at 40 mg/kg; induces tumor regression in an ST941/HI PDX mouse model