N6F11

A ferroptosis inducer; increases the thermal stability of TRIM25 in a CETSA using PANC-1 cells at 10 µM; enhances TRIM25-dependent ubiquitination of GPX4 in a cell-free assay at 0.1 and 1 µM; induces lipid peroxidation and ferroptosis, as well as degradation of GPX4, an effect that can be reversed by carfilzomib or bortezomib, in PANC-1 cells at 5 µM; selectively induces cytotoxicity in HT-1080, PANC-1, MiaPaCa-2, and Calu-1 cancer cells over neutrophils, dendritic cells, NK cells, and CD8+ T cells; decreases tumor volume in a KPC murine PDAC model at 10 mg/kg, which can be inhibited by liproxstatin-1 or an anti-CD8 antibody