Tirzepatide (sodium salt)
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≥95%
A solid
C225H348N48O68 • XNa
4813.5
l-tyrosyl-2-methylalanyl-l-α-glutamylglycyl-l-threonyl-l-phenylalanyl-l-threonyl-l-seryl-l-α-aspartyl-l-tyrosyl-l-seryl-l-isoleucyl-2-methylalanyl-l-leucyl-l-α-aspartyl-l-
A dual GLP-1R and GIP receptor agonist; induces cAMP production in HEK293 cells expressing human GLP-1R or human GIP receptor (EC50s = 6.54 and 1.01 nM, respectively); induces receptor internalization in HEK293 cells expressing human GLP-1R or GIP receptor at 100 nM; decreases body weight, food intake, plasma levels of leptin, triglycerides, and FFAs, hepatic levels of triglycerides, and blood glucose levels in a mouse model of high-fat diet-induced obesity at 10 nmol/kg per day; prevents A. alternata-induced increases in the numbers of eosinophils and lymphocytes levels in the BALF from A. alternata-challenged mice at 50 nmol/kg every three days; inhibits methacholine-induced bronchoconstriction in a mouse model of diabetes-induced asthma at 50 nmol/kg every three days