Col003

• MSDS: View or download

An inhibitor of the collagen-Hsp47 protein-protein interaction (IC50 = 1.8 µM); decreases procollagen secretion from, and reduces the collagen levels in the ECM of, primary MEFs at 100 µM; a PBP2 inhibitor (IC50 = 128 µM); decreases the growth of wild-type, penicillin-resistant, and penicillin- and cephalosporin-resistant N. gonorrhea strains (MIC50 = 4, 8, 16 µg/ml, respectively); reduces collagen-induced, but not arachidonic acid- or thrombin-induced, isolated rat platelet aggregation at 50 µM; increases the time to occlusion induced by ferric chloride in carotid arteries in rats at 50 µM; reduces brain infarct area and cell death, as well as improves grip strength, in a rat model of MCAO-induced ischemia-reperfusion injury at 50 µM