MK-8722

An AMPK activator; activates Ampk and increases phosphorylated Acc1 levels in primary mouse DRG at 0.1 and 10 µM; reduces the proliferation, colony formation, migration, and invasion of, and induces apoptosis in, PANC-1 and PaTu 8988 pancreatic cancer cells at 20 and 50 µM; induces cell cycle arrest at the G2 phase in PANC-1 and PaTu 8988 cancer cells at 50 µM; reduces tumor volume and weight in a PANC-1 mouse xenograft model at 25 mg/kg per day; decreases blood glucose levels in fasting and glucose-challenged mice in a mouse model of diabetes induced by a high-fat diet at 10 and 30 mg/kg; increases the paw withdrawal threshold in the von Frey test in mice at 30 mg/kg