PK68
Catalogue number:
CAY36653-25 mg
Supplier:
Size:
25 mg
Product is available in:
£807.00
Estimated delivery Thu 4 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2173556-69-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C22H24N4O3S
Molecular Weight:
424.51712
Alternative Names:
n-[5-[2-
Product Description:
A RIPK1 inhibitor (IC50 = 90 nM); selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM; inhibits necroptosis induced by TNF-α, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM); reduces the number of lung metastases in a B16/F10 murine melanoma model at 5 mg/kg; increases survival and prevents decreases in body temperature and increases in serum Il-1β levels in a mouse model of Tnf-α-induced SIRS at 1 mg/kg