PK68
Catalogue number:
CAY36653-25 mg
Supplier:
Size:
25 mg
Product is available in:
£807.00
Estimated delivery Mon 12 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2173556-69-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C22H24N4O3S
Molecular Weight:
424.51712
Alternative Names:
n-[5-[2-
Product Description:
A RIPK1 inhibitor (IC50 = 90 nM); selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM; inhibits necroptosis induced by TNF-α, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM); reduces the number of lung metastases in a B16/F10 murine melanoma model at 5 mg/kg; increases survival and prevents decreases in body temperature and increases in serum Il-1β levels in a mouse model of Tnf-α-induced SIRS at 1 mg/kg