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Fumagillol

Catalogue number:
CAY39766-10 mg
Supplier:
Size:
10 mg
Product is available in:
  • UK
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£1392.00 Estimated delivery Fri 8 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

108102-51-8

Purity:

≥95%

Formulation:

A solid

Molecular Formula:

C16H26O4

Molecular Weight:

282.4

Alternative Names:

(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-ol, (−)-fumagillol

Product Description:

A sesquiterpenoid with diverse biological activities; inhibits METAP2 (IC50 = 230 nM for the human enzyme); active against G. lamblia (IC50 = 3.4 µM); reduces the proliferation of isolated calf pulmonary artery endothelial cells (IC50 = 8.09 µM) and HUVECs (EC50 = 49 nM); inhibits the proliferation of isolated mouse splenocytes in a mixed lymphocyte reaction (IC50 = 250 nM)