PF-9363
Catalogue number:
CAY37778-25 mg
Supplier:
Size:
25 mg
Product is available in:
£971.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2569009-58-9
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C20H20N4O6S
Molecular Weight:
444.5
Alternative Names:
2,6-dimethoxy-
Product Description:
A KAT6A and KAT6B inhibitor (Kis = 0.27 and 2.4 nM, respectively); selective for KAT6A and KAT6B over KAT7, KAT5, and KAT8 (Kis = 70, 420, and 670 nM, respectively); reduces the proliferation of, and the levels of H3K23Ac and H3K14Ac in, ZR-75-1 cancer cells (IC50s = 0.37, 0.85, and 120 nM, respectively); reduces tumor levels of H3K23Ac and tumor volume without affecting body weight in a ZR-75-1 breast cancer mouse xenograft model at 0.03, 03, or 5 mg/kg per day; reduces tumor volume and increases survival in a PDX mouse model of breast cancer at 1 mg/kg per day