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(E/Z)-IT-603

Catalogue number:
CAY37792-25 mg
Supplier:
Size:
25 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£762.00 Estimated delivery Wed 15 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

292168-90-2

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C11H9BrN2O3S

Molecular Weight:

329.17084

Alternative Names:

5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone

Product Description:

A mixture of (E)-IT-603 and (Z)-IT-603; (Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM); (Z)-IT-603 inhibits c-Rel DNA binding in an EMSA; preincubation with mouse T cells prevents the development of GVHD but does not affect GVT activity in a mouse model of allogeneic hematopoietic stem cell transplantation at 20 µM