S1PL-IN-31
Catalogue number:
CAY39826-1 mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1538574-95-6
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C26H23ClN6
Molecular Weight:
455
Alternative Names:
6-[(2r)-4-[7-
Product Description:
An S1P lyase inhibitor (IC50 = 210 nM); an antagonist for Smo (IC50 = 440 nM); prevents cervical and thoracic lymphocyte infiltration and neuromuscular weakness in a rat model of MOG29-152-induced EAE at 2 mg/kg per day; reduces the total number of lymphocytes, as well as the levels of CD4+ T cells, CD8+ T cells, and B cells in rats; increases S1P levels in the heart and lymph nodes of male and female rats at 100 mg/kg; decreases heart rate in female rats at 3 and 10 mg/kg per day