Ripasudil (hydrochloride hydrate)
Catalogue number:
CAY19920-5 mg
Supplier:
Size:
5 mg
Product is available in:
£189.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
887375-67-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C15H18FN3O2S • HCl [2H2O]
Molecular Weight:
395.9
Alternative Names:
4-fluoro-5-
Product Description:
A ROCK1 and ROCK2 inhibitor (IC50s = 51 and 19 nM, respectively); selective for ROCK1 and ROCK2 over PKACα and PKC (IC50s = 2,100 and >10,000 nM, respectively); reduces intraocular pressure in cynomolgus monkey at 0.4%; increases the outflow facility of the aqueous humor in rabbit eyes at 0.4%; decreases intraocular pressure, retinal ganglion cell death, and thinning of inner retinal layers, as well as improves retinal function, in an EAAT1 knockout mouse model of normal tension glaucoma