£179.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
3004676-77-8
Purity:
≥90%
Formulation:
A solid
Molecular Formula:
C29H23Cl2NO4
Molecular Weight:
520.40266
Alternative Names:
1-[4′-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy][1,1′-biphenyl]-3-yl]-cyclopropanecarboxylic acid
Product Description:
An FXR agonist and inhibitor of FABP1; selectively induces reporter gene expression in HepG2 cells expressing human FXR (EC50 = 143 nM) over cells expressing 19 other receptors (EC50s = >10,000 nM for all); selectively inhibits FABP1 (IC50 = 2.7 µM) over FABP3 (IC50 = >30 µM) but also inhibits FABP4 (IC50 = 6.3 µM); induces FXR-related gene expression in the ileum but not the liver in a mouse model of carbon tetrachloride-induced NASH at 20 mg/kg; reduces hepatocyte ballooning, as well as hepatic lobular inflammation and steatosis in the same model