D159687
Catalogue number:
CAY38778-5 mg
Supplier:
Size:
5 mg
Product is available in:
£83.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1155877-97-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H19ClN2O2
Molecular Weight:
366.84054
Alternative Names:
n-[4-[(3′-chloro-6-methoxy[1,1′-biphenyl]-3-yl)methyl]phenyl]-urea
- MSDS: View or download
Product Description:
A PDE4D negative allosteric modulator (IC50 = 28 nM for the human enzyme); selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM); decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253 nM) and dextran gel-induced increases in leukotriene E4 production in isolated human whole blood (IC50 = 44 nM); impairs novel object recognition in mice at 3 mg/kg but does not increase anesthesia duration, a proxy measure of emesis induction, in mice at 3 or 10 mg/kg