AZD 8797
Catalogue number:
CAY28419-1 mg
Supplier:
Size:
1 mg
Product is available in:
£94.00
Estimated delivery Wed 10 Jun
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
911715-90-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C19H25N5OS2
Molecular Weight:
403.5669
Alternative Names:
(2r)-2-[[2-amino-5-[[(1s)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol
Product Description:
A CX3CR1 antagonist (Ki = 3.9 nM); selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM); inhibits CX3CL1-induced [35S]GTPγS accumulation in CHO cell membranes expressing human CX3CR1 from 0.1-10 µM; inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM); reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced EAE at 39 and 78 µmol/kg per day