Phospho beta Catenin Antibody Panel (Total, pS33, pS37, pT41 / pS45)

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β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Both Akt and PKA were shown to phosphorylate β-catenin at Ser552 and Ser675. Phosphorylation at Ser552 and Ser675 induces β-catenin accumulation in the nucleus and increases its transcriptional activity.This antibody panel investigates different processes through the phosphorylation on multiple site of β-Catenin. Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-305. Amit, S. et al. (2002) Genes Dev 16, 1066-76. Liu, C. et al. (2002) Cell 108, 837-47. Yanagawa, S. et al. (2002) EMBO J 21, 1733-42. Yost, C. et al. (1996) Genes Dev 10, 1443-54. Fang D et al. (2007) J Biol Chem 282, 11221–9. He, X.C. et al. (2007) Nat. Genet. 39, 189-198. ARG65351 Goat anti-Rabbit IgG antibody (HRP) 50 µl; ARG51618 anti-beta Catenin phospho (Thr41 / Ser45) antibody 50 µl; ARG51710 anti-beta Catenin phospho (Ser37) antibody 50 µl; ARG51709 anti-beta Catenin phospho (Ser33) antibody 50 µl; ARG52651 anti-beta Catenin antibody 50 µl;