C14-4
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2639634-80-1
≥95% (mixture of isomers)
A solution in ethanol
C84H173N5O7
1365.3
1,1′-[[2-[2-[4-
An ionizable cationic lipid; has been used in the generation of lipid nanoparticles for the delivery of mRNA in vitro or in vivo; LNPs containing C14-4 and encapsulating mRNA encoding CAR induce CAR expression in primary human T cells ex vivo to the same level as expression induced via electroporation, but with reduced cytotoxicity, and induce cytotoxicity in Nalm-6 ALL cells in vitro; LNPs containing C14-4 and deoxycholic acid and encapsulating mRNA encoding luciferase accumulate in the uterus when intraperitoneally administered and in the lungs and small intestine when intravenously administered in mice