Lipid A4

Name: Lipid A4
Brand: Cayman Chemical
SKU: CBSKU_201234770
Price: 104 GBP
Availability: InStock

Catalogue number:

Add to favourites

CAY38351-1 mg

Supplier:

Cayman Chemical

Size:

1 mg

Product is available in:

Currency:
GBP
EUR

£104.00

add to basket

Estimated delivery Mon 5 Jan
Shipping is calculated in checkout

This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

2639634-71-0

Purity:

≥95%

Formulation:

A solution in ethanol

Molecular Formula:

C74H153N5O7

Molecular Weight:

1225

Alternative Names:

1,1'-((2-(2-(4-(2-((2-(2-(bis(2-hydroxydodecyl)amino)ethoxy)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethoxy)ethyl)azanediyl)bis(dodecan-2-ol), c12–4, c12-49

MSDS: View or download

Product Description:

A branched-chain ionizable cationic lipidoid; has been used in the formation of LNPs for the delivery of mRNA; LNPs containing lipid A4 and encapsulating an mRNA reporter accumulate in the uterus, placenta, and ovaries, as well as to the spleen and liver, in pregnant mouse dams unlike LNPs containing C12-200, which primarily accumulate in the liver; intravenous administration of LNPs containing lipid A4 and encapsulating mRNA encoding VEGF increase placental VEGFR1 levels and mean fetal blood vessel area without inducing liver damage in pregnant mouse dams; LNPs containing lipid A4 and encapsulating mRNA encoding a chemiluminescent reporter cross the blood-brain barrier and induce reporter expression in the brains of mice