4A3-SC8
Catalogue number:
CAY38155-10 mg
Supplier:
Size:
10 mg
Product is available in:
£528.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1857340-78-3
Purity:
≥95%
Formulation:
A solution in methyl acetate
Molecular Formula:
C75H139N3O16S4
Molecular Weight:
1467.2
Product Description:
An ionizable cationic lipid and a dendrimer; has been used in the generation of LNPs for the delivery of siRNA, mRNA, sgRNA, ssDNA, and PEGylated BODIPY dyes; LNPs containing 4A3-SC8 and encapsulating siRNA targeting Factor VII selectively accumulate in the liver and decrease hepatic Factor VII activity in mice; intratumoral administration of LNPs containing 4A3-SC8 and encapsulating HDR elements correct the DNA encoding GFPY66H in a HEK293 mouse xenograft model; intravenous administration of LNPs containing 4A3-SC8 and encapsulating an mRNA reporter and a PEGylated BODIPY dye have been used for tumor imaging in mice