JNJ-10229570
Catalogue number:
CAY37768-5 mg
Supplier:
Size:
5 mg
Product is available in:
£360.00
Estimated delivery Tue 14 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
524923-88-4
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C22H19N3O2S
Molecular Weight:
389.47128
Alternative Names:
n-[2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2h)-ylidene]-benzenamine
Product Description:
A melanocortin receptor antagonist (IC50s = 270, 240, and 200 nM for MC1R, MC4R, and MC5R, respectively, in radioligand binding assays); prevents bovine pituitary extract-induced increases in lipid droplets in primary human sebocytes at 0.05 µM; inhibits cholera toxin-induced increases in squalene and cholesterol esters, but not triglycerides, in primary human sebocytes at 1 µM; topical application inhibits sebum secretion from, and sebaceous gland differentiation in, transplanted human skin in a mouse xenograft model at 0.05%