Quarfloxin
Catalogue number:
CAY36552-1 mg
Supplier:
Size:
1 mg
Product is available in:
£78.00
Estimated delivery Wed 17 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
865311-47-3
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C35H33FN6O3
Molecular Weight:
604.673563
Alternative Names:
5-fluoro-n-[2-
Product Description:
An inhibitor of RNA polymerase I-mediated transcription; binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin; induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells at 10 µM; induces apoptosis in A549 and HL-60 cells at 5 µM; reduces tumor growth in MDA-MB-231 and MiaPaCa-2 mouse xenograft models at 5 mg/kg