Panobinostat
Catalogue number:
BPS-27020
Supplier:
Size:
10 mg
Product is available in:
CAS Number:
404950-80-7
Purity:
≥99%
Molecular Formula:
C21H23N3O2
Molecular Weight:
349.4
Alternative Names:
Faridak, LBH-589
- Data sheet: View or download
Product Description:
Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50's against HDAC s 1-9 range between 3 - 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.
