CAS Number:
439081-18-2
Purity:
≥95% by HPLC.
Molecular Formula:
C24H25ClFN5O3
Molecular Weight:
485.9
Alternative Names:
BIW-2992
- Data sheet: View or download
Product Description:
Afatinib, also known as BIW-2992, is an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinases. Afatinib suppresses EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines, including EGFR-overexpressing and HER2-expressing cell lines A431, NIH-3T3-HER2, NCI-N87 and BT-474.
