AZD 1390
Catalogue number:
CAY36498-1 mg
Supplier:
Size:
1 mg
Product is available in:
£70.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2089288-03-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C27H32FN5O2
Molecular Weight:
477.573883
Alternative Names:
7-fluoro-1,3-
Product Description:
An inhibitor of ATM kinase (IC50 = 0.78 nM); selective for ATM over ATR, PI3K, mTOR, and DNA-PK (IC50s = >30, >12, >16, and >29.9 µM, respectively); sensitizes glioma cells expressing mutant, but not wild-type, p53 to ionizing radiation; reduces the growth of brain metastases and increases survival in an NCI H2228 mouse xenograft model at 20 mg/kg twice daily, p.o., in combination with radiation