CL4H6

An ionizable cationic lipid; has been used in the generation of LNPs encapsulating siRNA for use in vivo; LNPs containing CL4H6 and encapsulating siRNA targeting Factor VII decrease hepatic levels of Factor VII in mice; LNPs containing CL4H6 and encapsulating a reporter protein selectively accumulate in the liver, spleen, and tumors over the lungs and kidneys, as well as selectively accumulate in tumor-associated macrophages (TAMs) over tumor cells, neutrophils, and other leukocytes, in an OS-RC-2 renal cancer mouse xenograft model after intravenous administration; LNPs containing CL4H6 and encapsulating siRNAs targeting and encapsulating siRNAs targeting mRNA encoding Stat3 and Hif-1α increase the levels of M1 macrophages in the tumor microenvironment and decrease tumor volume in the same model