JTE-607
Catalogue number:
CAY36942-50 mg
Supplier:
Size:
50 mg
Product is available in:
£743.00
Estimated delivery Fri 1 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
188791-09-5
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C25H31Cl2N3O5 • 2HCl
Molecular Weight:
597.35754
Alternative Names:
n-[3,5-di
Product Description:
A cytokine synthesis inhibitor; inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human PBMCs (IC50s = 11, 5.9, 8.8, 7.3m and 9.1 nM, respectively); binds to CPSF3 in cell-free assays; induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells; reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock from 0.3-10 mg/kg, i.v.