Fadraciclib
Catalogue number:
CAY36119-10 mg
Supplier:
Size:
10 mg
Product is available in:
£601.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1070790-89-4
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C21H31N7O
Molecular Weight:
397.51742
Alternative Names:
(2r,3s)-3-[[6-
Product Description:
An inhibitor of Cdk2 and Cdk9 (IC50s = 4.5 and 20.5 nM, respectively); selective for Cdk2 and Cdk9 over Cdk1, -4, and -7 (IC50s = 278, 193, and 232 nM, respectively); inhibits the proliferation of COLO 205 cells (IC50 = 0.31 µM); inhibits proliferation in a panel of five breast cancer cell lines (IC50s = <0.4 µM for all); decreases phosphorylation of the RNA polymerase II C-terminal domain and RB and induces apoptosis in COLO 205 cells; reduces tumor volume in an EoL-1 mouse xenograft model at 40 and 55 mg/kg; inhibits tumor growth in an HL-60 mouse xenograft model at 70 mg/kg