4-oxo Retinoic Acid
Catalogue number:
CAY35819-25 mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
38030-57-8
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C20H26O3
Molecular Weight:
314.41864
Alternative Names:
4-keto atra, 4-oxo ra, all-trans-4-keto retinoic acid, all-trans-4-oxo ra, all-trans-4-oxo retinoic acid
Product Description:
An active metabolite of all-trans retinoic acid; binds to RARα, RARβ, and RARγ (IC50s = 59, 50, and 142 nM, respectively, in radioligand binding assays) and induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 33, 8, and 89 nM, respectively); increases protein levels of CK-7 and CK-19 in human epidermal keratinocytes at 1 µM; inhibits the proliferation of MCF-7 breast cancer cells at 10-1,000 nM; is teratogenic to zebrafish embryos (EC50 = 8.1 nM)