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ELOVL1-22

Catalogue number:
CAY36142-5 mg
Supplier:
Size:
5 mg
Product is available in:
  • UK
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£587.00 Estimated delivery Fri 2 Jan
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2761063-99-2

Purity:

≥98%

Formulation:

A solution in ethanol

Molecular Formula:

C21H23N5O2

Molecular Weight:

377.43982

Alternative Names:

(2s)-2-phenyl-4-[6-[[cis-3-(1h-pyrazol-1-yl)cyclobutyl]oxy]-4-pyrimidinyl]-morpholine

Product Description:

An inhibitor of ELOVL1; inhibits LPC(C26:0) synthesis in HEK293 cells (IC50 = 400 pM) and is selective for ELOVL1 over ELOVL4, -6, and -7 (IC50s = >50 µM for all), as well as a panel of 34 receptors at 10 µM; reduces blood and CNS levels of LPC(C26:0) in an Abcd1-/- mouse model of ALD from 1-32 mg/kg