MDL 800
Catalogue number:
CAY35528-5 mg
Supplier:
Size:
5 mg
Product is available in:
£70.00
Estimated delivery Wed 7 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2275619-53-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C21H16BrCl2FN2O6S2
Molecular Weight:
626.3
Alternative Names:
2-[[(5-bromo-
Product Description:
An allosteric SIRT6 activator; selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and HDAC1-11 deacetylase activity in cell-free assays at 100 µM; induces histone deacetylation (IC50 = 23.3 µM) in and reduces proliferation of BEL-7405 HCC cells (EC50 = 90.4 µM); inhibits OGD-induced TNF-α release in primary mouse microglia from 0.1-5 µM; reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model at 50, 100, and 150 mg/kg