MDL 800
Catalogue number:
CAY35528-5 mg
Supplier:
Size:
5 mg
Product is available in:
£70.00
Estimated delivery Thu 19 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2275619-53-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C21H16BrCl2FN2O6S2
Molecular Weight:
626.3
Alternative Names:
2-[[(5-bromo-
Product Description:
An allosteric SIRT6 activator; selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and HDAC1-11 deacetylase activity in cell-free assays at 100 µM; induces histone deacetylation (IC50 = 23.3 µM) in and reduces proliferation of BEL-7405 HCC cells (EC50 = 90.4 µM); inhibits OGD-induced TNF-α release in primary mouse microglia from 0.1-5 µM; reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model at 50, 100, and 150 mg/kg