MS1943
Catalogue number:
CAY35466-5 mg
Supplier:
Size:
5 mg
Product is available in:
£135.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2225938-17-8
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C42H54N8O3
Molecular Weight:
718.93028
Alternative Names:
n-[(1,2-di
Product Description:
A PROTAC that drives EZH2 degradation; inhibits EZH2 (IC50 = 120 nM) and is selective for EZH2 over EZH1, as well as a panel of 45 kinases at 10 µM; induces EZH2 degradation and reduces H3K27me3, as well as induces activation of the unfolded protein response pathway in MDA-MB-468 TNBC cells at 4 µM; inhibits the growth of MDA-MB-468 cells in vitro (GI50 = 2.2 µM); reduces tumor volume in an MDA-MB-468 mouse xenograft model at 50 mg/kg