3-Isomangostin

A xanthone with diverse biological activities; an inhibitor of MTH1 (IC50 = 52 nM); inhibits aldose reductase (IC50 = 3.48 µM), AChE (IC50 = 2.36 µg/ml), and BChE (IC50 = 5.32 µg/ml); inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 µg/ml, respectively); inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively)