Oxotremorine (sesquifumarate)
Catalogue number:
CAY35707-500 mg
Supplier:
Size:
500 mg
Product is available in:
£261.00
Estimated delivery Wed 5 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
17360-35-9
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C12H18N2O • 3/2C4H4O4
Molecular Weight:
380.4
Alternative Names:
1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-2-pyrrolidinone, 2e-butenedioate (2:3)
Product Description:
A muscarinic acetylcholine receptor agonist; binds to M1, M2, M3, and M4 mAChRs (Kis = 3.31, 9.33, 5.24, and 7.08 µM, respectively, for the human receptors); inhibits ACh release in rat cerebral cortical slices at 10 µM, an effect that can be reversed by atropine; induces tremors, salivation, and lacrimation in mice (ED50s = 0.11, 0.22, and 0.28 mg/kg); induces analgesia in the hot plate test in mice at 0.5 mg/kg; has been used to induce parkinsonian symptoms as a model of Parkinson's disease in mice