L-319
Catalogue number:
CAY35051-10 mg
Supplier:
Size:
10 mg
Product is available in:
£180.00
Estimated delivery Wed 24 Dec
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1351586-50-9
Purity:
≥95%
Formulation:
A 10 mg/ml solution in ethanol
Molecular Formula:
C41H75NO6
Molecular Weight:
678
Alternative Names:
9-[4-(dimethyl
Product Description:
An ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA; has been used in the formation of LNPs; administration of mouse FVII-targeting siRNA in L-319-containing LNPs reduce serum levels of FVII in mice; LNPs containing L-319 in combination with cKK-E12 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles