Abrocitinib
Catalogue number:
CAY34869-5 mg
Supplier:
Size:
5 mg
Product is available in:
£112.00
Estimated delivery Wed 22 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1622902-68-4
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C14H21N5O2S
Molecular Weight:
323.4
Alternative Names:
n-[cis-3-
Product Description:
A JAK1 inhibitor (IC50 = 0.029 µM); selective for JAK1 over JAK2, JAK3, and TYK2 (IC50s = 0.803, >10, and 1.253 µM, respectively) and a panel of 40 kinases at 1 µM; inhibits IFN-α-, IL-21-, or IL-27-induced phosphorylation of STAT3 (IC50s = 0.189, 0.511, and 0.271 µM, respectively) and IFN-γ-induced phosphorylation of STAT1 (IC50 = 0.163 µM) in isolated human whole blood; reduces paw edema in a rat model of adjuvant-induced arthritis at 1, 5, and 15 mg/kg