Tirabrutinib
Catalogue number:
HY-15771-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1351636-18-4
Purity:
99.65
Molecular Weight:
454.48
Alternative Names:
ONO-4059; GS-4059
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Tirabrutinib (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies[1][2][3][4]. Tirabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)