SEL120-34A (hydrochloride)
Catalogue number:
CAY27906-5 mg
Supplier:
Size:
5 mg
Product is available in:
£214.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1609452-30-3
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C15H18Br2N4 • XHCl
Molecular Weight:
414.13838
Alternative Names:
7,8-dibromo-
Product Description:
A dual inhibitor of Cdk8 and Cdk19 (IC50s = 4.4 and 10.4 nM, respectively); selective for Cdk8 and Cdk19 over a panel of CDK/cyclin complexes at 1 µM; inhibits IFN-γ-induced phosphorylation of STAT1 in HCT116 colon cancer cells at 0.1-5 µM; inhibits proliferation of MOLM-16, MV4-11, and KG-1 cells (GI50s = <1 µM); reduces tumor growth in a KG-1 mouse xenograft model at 60 mg/kg