SN-011
Catalogue number:
CAY34890-25 mg
Supplier:
Size:
25 mg
Product is available in:
£824.00
Estimated delivery Fri 26 Sep
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2249435-90-1
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C25H19FN2O4S
Molecular Weight:
462.5
Alternative Names:
n-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-[1,1′-biphenyl]-4-carboxamide, gun35901
Product Description:
A STING antagonist; binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in MEFs, BMDMs, and HFFs (IC50s = 127.5, 107.1, and 502.8 nM, respectively); impairs recruitment of IRF3 or TBK1 to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits HSV-1-induced translocation of STING from the ER to the Golgi at 1 µM; increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome at 5 mg/kg