Nav1.7 Blocker 52

Name: Nav1.7 Blocker 52
Brand: Cayman Chemical
SKU: CBSKU_100935200
Price: 138 GBP
Availability: InStock

Catalogue number:

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CAY34477-5 mg

Supplier:

Cayman Chemical

Size:

5 mg

Product is available in:

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£138.00

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Estimated delivery Tue 9 Jun
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

1211866-85-1

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C25H27F3N6O3

Molecular Weight:

516.515729

Alternative Names:

n-[2-methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]-acetamide, tc-n 1752, voltage-gated sodium channel 1.7

Product Description:

An inhibitor of Nav1.7 (IC50 = 0.17 µM); selective for Nav1.7 over hERG/Kv11.1, Nav1.5, and Nav1.8 (IC50s = >10, 1.1, and 2.2 µM, respectively) but does inhibit Nav1.3 and Nav1.4 (IC50s = 0.3 and 0.4 µM, respectively); inhibits formalin-induced flinching in a rat model of persistent pain at 20 and 30 mg/kg; increases latency to paw withdrawal in a hot plate test in a mouse model of CFA-induced inflammatory pain