DLin-MC3-DMA
Catalogue number:
CAY34364-25 mg
Supplier:
Size:
25 mg
Product is available in:
£179.00
Estimated delivery Tue 3 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1224606-06-7
Purity:
≥95%
Formulation:
A 100 mg/ml solution in ethanol
Molecular Formula:
C43H79NO2
Molecular Weight:
642.1
Alternative Names:
4-(dimethyl
Product Description:
An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity