DLin-MC3-DMA
Catalogue number:
CAY34364-25 mg
Supplier:
Size:
25 mg
Product is available in:
£118.00
Estimated delivery Thu 6 Nov
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1224606-06-7
Alternative Names:
4-(dimethylamino)-butanoic acid, (10z,13z)-1-(9z,12z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester, dilinoleyl-methyl-4-dimethylaminobutyrate, mc3
Product Description:
An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity