DLin-KC2-DMA

Name: DLin-KC2-DMA
Brand: Cayman Chemical
SKU: CBSKU_100935020
Price: 118 GBP
Availability: InStock

Catalogue number:

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CAY34363-10 mg

Supplier:

Cayman Chemical

Size:

10 mg

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£118.00

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Estimated delivery Wed 20 May
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

1190197-97-7

Purity:

≥98%

Formulation:

A 10 mg/ml solution in ethanol

Molecular Formula:

C43H79NO2

Molecular Weight:

642.1

Alternative Names:

n,n-dimethyl-2,2-di-(9z,12z)-9,12-octadecadien-1-yl-1,3-dioxolane-4-ethanamine, kc2

Product Description:

An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model