Anle138b

An inhibitor of protein aggregation; inhibits α-synuclein oligomer formation and PrPSc prion propagation at 10 µM; inhibits brain accumulation of PrPSc in, and increases survival of, prion-infected mice at 1 mg/animal; reduces brain tau deposition and rescues glucose metabolic decline in a human tau transgenic mouse model of Alzheimer’s disease; dietary administration reduces the formation of α-synuclein oligomers and glial cytoplasmic inclusions, microglial activation, and dopaminergic neuron degradation, as well as preserves motor function, in a mouse model of MSA at 0.6 and 2 g/kg chow