This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2377916-66-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C33H31ClN2O4
Molecular Weight:
555.06302
Alternative Names:
n-[[5-chloro-2-
Product Description:
A PD-1/PD-L1 interaction inhibitor (IC50 = 12.5 nM in an HTRF assay); increases IFN-γ production by isolated human PMBCs in co-culture with anti-CD3 single-chain variable fragment- and PD-L1-expressing Hep3B hepatoma cells (EC50 = ~3 µM); reduces tumor growth in a B16/F10 murine melanoma model and an H22 murine hepatocellular carcinoma model at 25, 50, and 100 mg/kg