AG-556

An EGFR inhibitor (IC50 = 5 µM); selective for EGFR over HER2 (IC50 = >500 µM); inhibits EGF-induced growth of HER14 cells (IC50 = 3 µM); inhibits hydrogen peroxide-induced increases in intracellular calcium in HEK293 cells expressing TRPM2 (IC50 = 0.94 µM), as well as HEK293 cells expressing TRPA1 at 3 µM; reduces the incidence, severity, and duration of disease in a mouse model of EAE at 200 µg/animal per day; reduces edema, demyelination, and MPO activity in spinal cord tissue, as well as improves motor function in a mouse model of extradural compression-induced spinal cord injury at 10 mg/kg