BAY-2402234
Catalogue number:
CAY33259-10 mg
Supplier:
Size:
10 mg
Product is available in:
£1069.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2225819-06-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H18ClF5N4O4
Molecular Weight:
520.8
Alternative Names:
n-(2-chloro-
Product Description:
A DHODH inhibitor (IC50 = 1.2 nM); induces CD11b upregulation in MOLM-13 and HEL AML cells (EC50s = 3.16 and 0.96 nM, respectively); inhibits the proliferation of nine leukemia cell lines (IC50s = 0.08-8.2 nM); induces cell cycle arrest at the G2/M phase and apoptosis in TF-1 cells; reduces tumor volume in an MV4-11 mouse xenograft model at 1.25, 2.5, and 5 mg/kg; increases survival in PDX mouse models of AML