www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

ONO-7475

Catalogue number:
CAY33258-10 mg
Supplier:
Size:
10 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£467.00 Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

1646839-59-9

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Formula:

C32H26N4O6

Molecular Weight:

562.5722

Alternative Names:

n-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide

Product Description:

An inhibitor of Axl and Mer (IC50s = 0.7 and 1 nM, respectively); selective for Axl and Mer over FLT3 (IC50 = 147 nM); reduces viability of, and induces apoptosis in, MOLM-13 and MV4-11 leukemia cells at 10 nM; reduces leukemic burden and increases the median survival time in a MOLM-13 mouse xenograft model at 6 mg/kg