MLi-2
Catalogue number:
CAY19305-10 mg
Supplier:
Size:
10 mg
Product is available in:
£393.00
Estimated delivery Wed 17 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1627091-47-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H25N5O2
Molecular Weight:
379.4557
Alternative Names:
rel-3-[6-
Product Description:
An LRRK2 inhibitor (IC50 = 0.76 nM); >100-fold selective for LRRK2 over a panel of 308 protein kinases, as well as a panel of receptors and ion channels, at 10 µM; increases GCase activity in dopaminergic neurons differentiated from induced pluripotent stem cells generated from skin fibroblasts isolated from patients with Parkinson's disease expressing LRRK2 mutations at 600 nM; inhibits cortical LRRK2 phosphorylation in the MitoPark mouse model of Parkinson's disease at 30 mg/kg