MLi-2
Catalogue number:
CAY19305-10 mg
Supplier:
Size:
10 mg
Product is available in:
£432.00
Estimated delivery Fri 9 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1627091-47-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H25N5O2
Molecular Weight:
379.4557
Alternative Names:
rel-3-[6-
Product Description:
An LRRK2 inhibitor (IC50 = 0.76 nM); >100-fold selective for LRRK2 over a panel of 308 protein kinases, as well as a panel of receptors and ion channels, at 10 µM; increases GCase activity in dopaminergic neurons differentiated from induced pluripotent stem cells generated from skin fibroblasts isolated from patients with Parkinson's disease expressing LRRK2 mutations at 600 nM; inhibits cortical LRRK2 phosphorylation in the MitoPark mouse model of Parkinson's disease at 30 mg/kg