SM-102

An ionizable cationic lipid (pKa = 6.68); has been used in the generation of LNPs for the delivery of mRNA and plasmid DNA in vitro and in vivo; inhibits hERG-mediated inward-rectifying potassium currents in GH3 and MA-10 cells (IC50s = 108 and 98 µM, respectively); administration of luciferase mRNA in SM-102-containing LNPs induces hepatic luciferase expression in mice; LNPs containing a SM-102 and Q1-SM-102 as a CLP and encapsulating a luciferase reporter induce luciferase expression in the lungs and spleen in mice; intramuscular immunization of LNPs containing SM-102 and encapsulating SARS-CoV-2 spike glycoprotein mRNA increases serum SARS-CoV-2 spike glycoprotein-specific IgG titers in mice; LNPs containing SM-102 and encapsulating mRNA encoding β-catenin increase bone volume in a mouse model of tibia fracture repair when administered via injection to the fracture callus