RIPA-56

A RIPK1 inhibitor (IC50 = 13 nM); selective for RIPK1 over RIPK3 at 10 µM, as well as over a panel of additional kinases at 2 µM; inhibits Z-VAD-FMK-induced necrosis in HT-29 cells (EC50 = 28 nM); reduces TNF-α-induced lethality and protects against TNF-α-induced organ damage in a mouse model of SIRS at 6 mg/kg; reduces spinal cord demyelination and BBB breakdown in a mouse model of EAE; reduces hepatic inflammatory cell infiltration and fibrosis, as well as body weight gain and total fat mass, in a mouse model of high-fat diet-induced NASH at 300 mg/kg