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NS 5806

Catalogue number:
CAY33226-25 mg
Supplier:
Size:
25 mg
Product is available in:
  • UK
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£738.00 Estimated delivery Wed 22 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

426834-69-7

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Formula:

C16H8Br2F6N6O

Molecular Weight:

574.1

Alternative Names:

n-[3,5-bis(trifluoromethyl)phenyl]-n′-[2,4-dibromo-6-(2h-tetrazol-5-yl)phenyl]-urea

Product Description:

An Ito current activator; increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a KChIP2-dependent manner, in CHO-K1 cells expressing human KV4.3; increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM); reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog model of heart failure